netFormulary NHS
NHS Bath and North East Somerset, Swindon and Wiltshire CCG
Royal United Hospitals Bath NHS Foundation Trust
Great Western Hospitals NHS Foundation Trust
Salisbury NHS Foundation Trust
 Formulary Chapter 4: Central nervous system - Full Chapter

CNS-related Prescribing Guidance

Please see our Prescribing Guidelines page for all prescribing guidance relating to this chapter.

CNS-related Shared Care Agreements

Please see our Shared Care Agreements page for all shared care agreements (SCAs) relating to this chapter.


04.09.01  Expand sub section  Dopaminergic drugs used in Parkinsons disease

Dopamine receptor agonists

Restless Legs

All other possible causes of symptoms should be excluded before prescribing for restless leg syndrome.  In patients with a serum ferritin of less than 50mcg/l, prescribing oral iron supplements resolves symptoms in approx. 50% of cases.

Where all other causes have been excluded, plain ropinirole may be considered for moderate to severe idiopathic RLS. Where plain ropinirole is prescribed, the patient should be reviewed after 3 months and ropinirole discontinued if no effect has been seen.

A CCG Individual Funding Request should be made prior to initiation of any other treatment for RLS e.g. pramipexole or rotigotine.

Useful further information: BMJ Feb 2017 New concepts in the management of restless legs syndrome

04.09.01  Expand sub section  Dopamine receptor agonists
04.09.01  Expand sub section  Levodopa
04.09.01  Expand sub section  Monoamine-oxidase-B inhibitors
04.09.01  Expand sub section  Catachol-O-methyltransferase inhibitors to top
04.09.01  Expand sub section  Amantadine
View adult BNF View SPC online
  • Capsules 100mg
  • Syrup 50mg in 5ml
  • For Parkinsons Disease
  • 'Off label' for the treatment of fatigue in Multiple Sclerosis according to NICE CG186 Oct14 
Link  NICE CG186 Multiple sclerosis in adults: management (Nov 19 update)
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Traffic Light Status Information

Status Description


RED - Hospital only – to be prescribed by a specialist and supplied from secondary care ONLY throughout treatment.  


Amber medicines are considered suitable for GP prescribing following specialist initiation or recommendation.  

Amber with Shared Care

Shared Care - these medicines require specialist initiation and stabilisation. Ongoing division of responsibility for drug and disease monitoring between specialist and GP by a Shared Care Guideline (SCG). If no SCG in place status reverts to red.  


These medicines are appropriate for initiation in both primary and secondary care. Prescribing is appropriate within licensed or local recommendations.  


Suitable for patient to be directed to buy themselves  


Not currently used. We intend to include this TLS in future to highlight where a decision to use this medicine is under review.   


Not currently used. We intend to include this TLS in future to highlight where a decision has been made by either or both the local or national NHS not to routinely commission this preparation for its licensed indications. Do not prescribe.  

Red Specialist Centre

Not currently used. We intend to include this TLS in future to highlight where this medicine and indication is ONLY available through a Specialist Centre according to a NICE Highly Specialised Technology or NHSE Specialised Commission Circular / Policy.