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 Formulary Chapter 8: Malignant disease and immunosuppression - Full Chapter
Notes:

Hameatology/Oncology related Prescribing Guidance

Please see our Prescribing Guidelines page for all prescribing guidance relating to this chapter.

Haematology/Oncology related Shared Care Agreements

Please see our Shared Care Agreements page for all shared care agreements (SCAs) relating to this chapter.

 

 Details...
08.01  Expand sub section  Cytotoxic drugs
08.01  Expand sub section  Drugs for cytotoxic-induced side-effects
Calcium Folinate
(Injection)
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Formulary
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  • Folinic acid (as Calcium folinate) 7.5mg per 1ml
  • Chemotherapy induced mucositis and myelosuppression
 
 
Mesna
(Injection)
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Formulary
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  • 1m/10ml solution for injection
  • Chemotherapy induced neutropenic infection and nephrotoxicity
 
 
Mesna
(Tablets)
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Formulary
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  • 400mg or 600mg tablets
  • Chemotherapy induced neutropenic infection and nephrotoxicity
 
 
08.01.01  Expand sub section  Alkylating drugs
Bendamustine
(Injection)
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Formulary
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High Cost Medicine
NHS England

 

 
Link  NICE TA216: Bendamustine for CLL
Link  NICE TA649 Polatuzumab vedotin with rituximab and bendamustine for treating relapsed or refractory diffuse large B-cell lymphoma
 
Busulfan
(Tablets)
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Formulary
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  • 2mg tablets
 
 
Busulfan
(Injection)
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Formulary
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  • 60mg/10ml infusion
 
 
Cyclophosphamide
(Tablets)
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Formulary
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  • 50mg tablets
 
 
Cyclophosphamide
(Injection)
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Formulary
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  • 500mg,1g and 2g injection 
 
 
Ifosfamide
(Injection)
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Formulary
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  • 1g and 2g injection
 
 
Lomustine
(Capsules)
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Formulary
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  • 40mg capsules
 
 
Melphalan
(Tablets)
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Formulary
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  • 2mg tablets
 
 
Melphalan
(Injection)
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Formulary
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  • 50mg powder and solvent for injection
 
 
Chlormethine Hydrochloride (Mustine)
(Injection )
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Unlicensed Drug Unlicensed
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  • 10mg powder for reconstitution
 
 
08.01.02  Expand sub section  Anthracyclines and other cytotoxic antibiotics
Bleomycin
(Injection)
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Formulary
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  • 15,000 unit powder for injection
 
 
Dactinomycin
(Injection)
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Formulary
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  • 500microgram powder for reconstitution
 
 
Daunorubicin
(Injection)
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Formulary
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  • 20mg infusion
 
 
Doxorubicin
(Injection)
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Formulary
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  • 10mg/5ml, 50mg/25ml, 100mg/50ml and 200mg/100ml injection
 
 
Doxorubicin (Caelyx®)
(Liposomal injection)
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Formulary
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High Cost Medicine
NHS England
 
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
 
Epirubicin
(Injection)
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Formulary
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  • 10mg/5ml and 50mg/25ml injection
  • 100mg/50ml, 200mg/100ml infusion
 
 
Idarubicin
(Injection and capsules)
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Formulary
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  • 5mg, 10mg and 25mg capsules
  • 5mg and 10mg injection
 
 
Mitomycin
(Injection)
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Formulary
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  • 2mg and 10mg injection
 
 
Mitoxantrone
(Injection)
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Formulary
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  • 20mg/10ml infusion
 
 
Pixantrone
(Injection)
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Formulary
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High Cost Medicine
NHS England
  • 29mg powder for infusion

 

 
Link  NICE TA306: Pixantrone monotherapy
 
08.01.03  Expand sub section  Antimetabolites to top
Azacitidine
(Injection)
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Formulary
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High Cost Medicine
NHS England
  • 100mg injection
 
Link  NICE TA218: azacitidine for myelodysplastic syndromes
 
Capecitabine
(Tablets)
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Formulary
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  • 150mg and 500mg tablets
 
Link  NICE TA100: Colon cancer (adjuvant) - capecitabine and oxaliplatin
Link  NICE TA191: Gastric cancer (advanced) - capecitabine
 
Cladribine
(Injection)
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Formulary
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High Cost Medicine
  • 10mg tablet
  • 10mg/10ml solution for infusion
  • 10mg/5ml solution for injection
  • For specialist use only in accordance with guidance from cancer network or NICE
 
Link  NICE TA616: Cladribine for treating relapsing–remitting multiple sclerosis
 
Cytarabine
(Injection)
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Formulary
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  • 100mg/5ml, 500mg/25ml, 1g/10ml, 2g/20ml and 500g/5ml injection
 
 
Fludarabine Phosphate (Injection)
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Formulary
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  • 50mg/2ml injection
 
Link  NICE TA119: Leukaemia (lymphocytic) - fludarabine
Link  NICE TA29: Leukaemia (lymphocytic) - fludarabine
 
Fludarabine Phosphate (Tablets)
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Formulary
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  • 10mg tablets
 
Link  NICE TA29: Leukaemia (lymphocytic) - fludarabine
 
Fluorouracil
(Injection)
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Formulary
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  • 250mg/10ml, 500ml/20ml, 500mg/10ml and 1g/20ml injection
  • 2.5mg/100ml, 2.5mg/50ml and 5mg/100ml infusion
  • For topical cream see chapter 13.8.1

 

 
 
Gemcitabine
(Injection)
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Formulary
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  • Various strengths of infusion
 
Link  NICE TA116: Breast cancer - gemcitabine
Link  NICE TA25: Pancreatic cancer - gemcitabine
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
 
Mercaptopurine
(Tablets)
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Formulary
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  • 50mg tablets
  • Note: Only the 50mg strength tablets are included on the formulary for gastro indications in adults10mg strength tablets are unlicensed specials. Alternate dosing using 50mg/100mg should be considered where daily doses between 50 and 100mgs are required for adults.
  • For use in children see paediatric chapter
  • For use in Crohn's disease, see chapter 1
 
 
Methotrexate
(Tablets)
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Formulary
traffic lightRed

 

 
 
Pemetrexed
(Injection)
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Formulary
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High Cost Medicine
NHS England
 
Link  NICE TA135: Mesothelioma - pemetrexed disodium
Link  NICE TA181: Lung cancer (non-small cell, first line treatment) - pemetrexed
Link  NICE TA190: Lung cancer (non-small-cell) - pemetrexed (maintenance)
Link  NICE TA402: Pemetrexed maintenance treatment for non-squamous non-small-cell lung cancer after pemetrexed and cisplatin
 
Clofarabine
(Injection)
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Unlicensed Drug Unlicensed
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High Cost Medicine
  • 20mg/20ml infusion
  • ONLY Approved for use in acute myeloblastic leukaemia in accordance with the criteria set out by the NHS England Cancer Drugs Fund

 

 

 
 
08.01.04  Expand sub section  Vinca alkaloids and etoposide
Etoposide
(Injection)
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Formulary
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  • 100mg/5ml, 200mg/10ml and 500mg/25ml infusion
 
 
Etoposide
(Capsules)
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Formulary
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  • 50mg and 100mg capsules
 
 
Vinblastine Sulphate (Injection)
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Formulary
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  • 1mg/10ml solution for injection
 
 
Vincristine Sulphate (Injection )
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Formulary
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  • 1mg/1ml, 2mg/2ml and 5mg/5ml injection 
 
 
Vindesine Sulphate
(Injection)
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Formulary
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  • 5mg injection
 
 
Vinorelbine
(Capsules)
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Formulary
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  • 20mg, 30mg and 80mg capsules
 
 
Vinorelbine
(Injection)
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Formulary
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  • 10mg/1ml and 50mg/5ml infusion
 
 
08.01.05  Expand sub section  Other antineoplastic drugs
Abemaciclib
(Tablets)
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Formulary
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High Cost Medicine
NHS England
  • 50mg, 100mg, 150mg film coated tablets
 
Link  NICE TA563: Abemaciclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer
Link  NICE TA579: Abemaciclib with fulvestrant for treating hormone receptor-positive, HER2-negative advanced breast cancer after endocrine therapy
 
Atezolizumab
(Injection)
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Formulary
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High Cost Medicine
NHS England
 
Link  NICE TA492: Atezolizumab for untreated locally advanced or metastatic urothelial cancer when cisplatin is unsuitable
Link  NICE TA520 : Atezolizumab for treating locally advanced or metastatic non-small-cell lung cancer after chemotherapy
Link  NICE TA525: Atezolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy
Link  NICE TA584: Atezolizumab in combination for treating metastatic non-squamous non-small-cell lung cancer
 
Avelumab
(injection)
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Formulary
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  • 200mg/10ml concentrate for solution for infusion vials
  • For use in combination with axitinib in line with NICE TA645 [Not at SFT]
 
Link  NICE TA517: Avelumab for treating metastatic Merkel cell carcinoma
Link  NICE TA645 Avelumab with axitinib for untreated advanced renal cell carcinoma
 
Axitinib
(Tablets)
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Formulary
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High Cost Medicine
NHS England
  • 1mg, 3mg, 5mg and 7mg tablets
 
Link  NICE TA333: Axitinib for advanced renal cell carcinoma
Link  NICE TA645 Avelumab with axitinib for untreated advanced renal cell carcinoma
 
Bosutinib
(Tablets)
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Formulary
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High Cost Medicine
NHS England
 
Link  NICE TA401: Bosutinib for previously treated chronic myeloid leukaemia
 
Brigatinib
(Tablets)
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Formulary
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  • 30mg, 90mg and 180mg
 
Link  NICE TA571 :Brigatinib for treating ALK-positive advanced non-small-cell lung cancer after crizotinib
 
Cabozantinib
(Tablets)
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Formulary
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High Cost Medicine
NHS England
  • 20mg, 40mg and 60mg tablets
 
Link  NICE TA542: Cabozantinib for untreated advanced renal cell carcinoma
 
Carfilzomib
(Injection)
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Formulary
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NHS England
  • 10mg, 30mg and 60mg infusion
 
Link  NICE TA457 : Carfilzomib for previously treated multiple myeloma
Link  NICE TA657: Carfilzomib for previously treated multiple myeloma
Link  MHRA November 2019 - Carfilzomib (Kyprolis▼): risk of reactivation of hepatitis B virus
Link  MHRA August 2019 - Carfilzomib (Kyprolis▼): reminder of risk of potentially fatal cardiac events
 
Ceritinib
(Capsules)
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Formulary
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High Cost Medicine
NHS England
  • 150mg capsules
 
Link  NICE TA395: Ceritinib for previously treated anaplastic lymphoma kinase positive non-small-cell lung cancer
Link  NICE TA500: Ceritinib for untreated ALK-positive non-small-cell lung cancer
 
Dabrafenib
(Capsules)
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Formulary
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High Cost Medicine
NHS England
  • 50mg and 75mg capsules

 

 
Link  NICE TA321:Dabrafenib for BRAF V600 +ve melanoma
Link  NICE TA396:Trametinib in combination with dabrafenib for treating unresectable or metastatic melanoma
Link  NICE TA544: Dabrafenib with trametinib for adjuvant treatment of resected BRAF V600 mutation-positive melanom
 
Daratumumab
(Injection)
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Formulary
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High Cost Medicine

 

 
Link  MHRA Drug Safety Update (Aug 2019): Daratumumab (Darzalex¥): risk of reactivation of hepatitis B virus
 
Defibrotide
(Injection)
Restricted Drug Restricted
traffic lightRed
High Cost Medicine
NHS England
  • 200mg (80 mg/mL concentrate for solution for infusion)
  • For the treatment of veno-occlusive disease in accordance with treatment of possible hepatic veno-occlusive disease as noted in link below
  • Formulary at RUH for this indication
 
Link  Inotuzumab ozogamicin for treating relapsed or refractory B-cell acute lymphoblastic leukaemia
 
Durvalumab
(Injection)
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Formulary
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High Cost Medicine
NHS England
  • 50 mg/mL concentrate for solution for infusion

 

 
Link  NICE TA578: Durvalumab for treating locally advanced unresectable non-small-cell lung cancer after platinum-based chemoradiation
 
Eribulin
(Injection)
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Formulary
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High Cost Medicine
NHS England
  • 0.88mg/2ml solution for injection

 

 
Link  NICE TA423: Eribulin for treating locally advanced or metastatic breast cancer after 2 or more chemotherapy regimens
 
Ibrutinib
(Capsules)
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Formulary
traffic lightRed
High Cost Medicine
 
Link  NICE TA429 : Ibrutinib for previously treated chronic lymphocytic leukaemia and untreated chronic lymphocytic leukaemia with 17p deletion or TP53 mutation
Link  NICE TA502: Ibrutinib for treating relapsed or refractory mantle cell lymphoma
 
Idelalisib
(Tablets)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 100mg and 150mg tablets
 
Link  NICE TA359: Chronic lymphocytic leukaemia - Idelalisib
 
Inotuzumab Ozogamicin (Injection)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 1mg infusion

 

 
Link  NICE TA541: Inotuzumab ozogamicin for treating relapsed or refractory B-cell acute lymphoblastic leukaemia
 
Isatuximab
(injection)
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Formulary
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  • 20mg/ml concentrate for solution for infusion vials
  • For use in combination with pomalidomide and dexamethasone for treating relapsed and refractory multiple myeloma in line with TA658.
    axitinib in line with NICE TA645
 
Link  NICE TA658: Isatuximab with pomalidomide and dexamethasone for treating relapsed and refractory multiple myeloma
 
Ixazomib
(Capsules)
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Formulary
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High Cost Medicine
BlueTeq
  • 2.3mg, 3mg and 4mg capsules
  • To treat relapsed/defractory myeloma in combination with Lenalidomaide and Dexamethasone
  • To treat multple myeloma via the Cancer Drugs Fund
 
 
Lenvatinib
(Capsules)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 4mg and 10mg capsules
  • Different brand depending upon indication

 

 
Link  NICE TA535: Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine
Link  NICE TA551: Lenvatinib for untreated advanced hepatocellular carcinoma
 
Lenvatinib with Everolimus
(Capsules)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 4mg and 10mg capsules
  • Different brand depending upon indication

 

 
Link  NICE TA498: Lenvatinib with everolimus for previously treated advanced renal cell carcinoma
 
Midostaurin
(Capsules)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 25mg capsules
 
Link  NICE TA523: Midostaurin for untreated acute myeloid leukaemia
 
Nintedanib
(Capsules)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 100mg and 150mg capsules

 

 
Link  NICE TA347 For treating locally advanced, metastatic or locally recurrant non-small-cell lung cancer
 
Palbociclib
(Capsules)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 75mg, 100mg and 125mg capsules

 

 
Link  NICE TA495 Palbociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic brest cancer
Link  NICE TA619 Palbociclib with fulvestrant for treating hormone receptor-positive, HER2-negative, advanced breast cancer
 
Panitumumab
(Injection)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 100mg/5ml and 400mg/20ml infusion

 

 
Link  NICE TA439 : Cetuximab and panitumumab for previously untreated metastatic colorectal cancer
 
Pembrolizumab
(Injection)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 100mg/4ml concentration for solution for infusion
  • 50mg powder for concentration for solution for infusion
  • Also available from NHS England Cancer Drugs Fund
  • NICE does not recommend pembrolizumab with axitinib for untreated advanced renal cell carcinoma (TA650).
 
Link  NICE TA357: Pembrolizumab for melanoma after ipilimumab
Link  NICE TA366: Pembrolizumab for advanced melanoma not previously treated with ipilimumab
Link  NICE TA428: Pembrolizumab for treating PD-L1-positive non-small-cell lung cancer after chemotherapy
Link  NICE TA531: Pembrolizumab for untreated PD-L1-positive metastatic non-small-cell lung cancer
Link  NICE TA650: Pembrolizumab with axitinib for untreated advanced renal cell carcinoma (not recommended)
Link  NICE TA661: Pembrolizumab for untreated metastatic or unresectable recurrent head and neck squamous cell carcinoma
 
Polatuzumab vedotin
(Injection)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 140mg powder for concentrate for solution for infusion vials
  • For use in combination with rituximab and bendamustine in line with NICE TA649

 

 
Link  NICE TA649 Polatuzumab vedotin with rituximab and bendamustine for treating relapsed or refractory diffuse large B-cell lymphoma
 
Ponatinib
(Tablets)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 15mg, 30mg and 45mg tablets

 

 
Link  NICE TA451 : Ponatinib for treating chronic myeloid leukaemia and acute lymphoblastic leukaemia
 
Ruxolitinib
(Tablets)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 5mg, 10mg, 15mg and 20mg tablets
 
Link  NICE TA386: Ruxolitinib for treating disease-related splenomegaly or symptoms in adults with myelofibrosis
 
Trametinib
(Tablets)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 0.5mg and 2mg tablets

 

 
Link  MHRA: Trametinib (Mekinist¥): risk of gastrointestinal perforation and colitis
Link  NICE TA396: Trametinib in combination with dabrafenib for treating unresectable or metastatic melanoma
Link  NICE TA544: Dabrafenib with trametinib for adjuvant treatment of resected BRAF V600 mutation-positive melanoma
 
Trifluridine-tipiracil (Tablets )
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Formulary
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High Cost Medicine
NHS England
  • 15mg/6.14mg and 20mg/8.19mg tablets
 
Link  NICE TA405: Trifluridine–tipiracil for previously treated metastatic colorectal cancer
 
Venetoclax
(Tablets)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
 
Link  NICE TA561: Venetoclax with rituximab for previously treated chronic lymphocytic leukaemia
 
08.01.05  Expand sub section  Amsacrine
Amsacrine
(Injection)
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Formulary
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  • 75mg/1.5ml solution for infusion ampoules and diluent
 
 
08.01.05  Expand sub section  Arsenic trioxide
Arsenic Trioxide
(Injection)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 10mg/10ml infusion
 
Link  NICE TA526: Arsenic trioxide for treating acute promyelocytic leukaemia
 
08.01.05  Expand sub section  Bortezomib to top
Bortezomib
(Injection)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
 
Link  NICE TA129: Multiple myeloma - bortezomib
Link  NICE TA228: 1st line treatment of multiple myeloma
Link  NICE TA311: Bortezomib for induction therapy in multiple myeloma
Link  NICE TA370: Bortezomib for previously untreated mantle cell lymphoma
 
08.01.05  Expand sub section  Brentuximab vedotin
Brentuximab
(Injection)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
 
Link  NICE TA478 Brentuximab vedotin for treating relapsed or refractory systemic anaplastic large cell lymphoma
Link  NICE TA524: Brentuximab vedotin for treating CD30-positive Hodgkin lymphoma
Link  NICE TA577 Brentuximab vedotin for treating CD30-positive cutaneous T-cell lymphoma
Link  NICE TA641 Brentuximab vedotin in combination for untreated systemic anaplastic large cell lymphoma
 
08.01.05  Expand sub section  Cetuximab
Cetuximab
(Injection)
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Formulary
traffic lightRed
High Cost Medicine
 
Link  NICE TA145: Head and neck cancer - cetuximab
Link  NICE TA439 : Cetuximab and panitumumab for previously untreated metastatic colorectal cancer
Link  NICE TA473: Cetuximab for treating recurrent or metastatic squamous cell cancer of the head and neck
 
08.01.05  Expand sub section  Dacarbazine and Temozolomide
Dacarbazine
(Injection)
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Formulary
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  • 500mg and 1g infusion
  • 100mg and 200mg injection
 
 
Temozolomide
(Capsules)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 5mg, 20mg, 100mg, 140mg, 180mg and 250mg capsules

 

 
Link  NICE TA121: Glioma (newly diagnosed and high grade)
Link  NICE TA23: Guidance on the use of temozolomide for the treatment of recurrent malignant glioma (brain cancer)
 
08.01.05  Expand sub section  Erlotinib
Erlotinib
(Tablets)
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Formulary
traffic lightRed
High Cost Medicine
  • 25mg, 100mg and 150mg tablets
 
Link  NICE TA227: Lung cancer (non-small-cell) maintenance - erlotinib
Link  NICE TA258: Lung cancer (non-small-cell) 1st line- erlotinib
Link  NICE TA374: Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy
 
08.01.05  Expand sub section  Hydroxycarbamide to top
Hydroxycarbamide
(Capsules)
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Formulary
  • Red  RUH 
  • Amber with Shared Care SFT and GWR
  • 500mg capsules
 
Link  3Ts Hydroxycarbamide Shared Care Document
Link  SFT Hydroxycarbamide Shared Care Document
 
08.01.05  Expand sub section  Ipilimumab
Ipilimumab
(Injection)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
 
Link  NICE TA268: Ipilimumab for previously treated advanced (unresectable or metastatic) melanoma
Link  NICE TA319: Ipilimumab for previously untreated advanced (unresectable or metastatic) melanoma
Link  NICE TA400: Nivolumab in combination with ipilimumab for treating advanced melanoma
Link  MHRA Drug Safety Update (Jan 2019):Ipilimumab (Yervoy): reports of cytomegalovirus (CMV) gastrointestinal infection or reactivation
 
08.01.05  Expand sub section  Pentostatin
Pentostatin
(Injection)
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Formulary
traffic lightRed
  • 10mg infusion

 

 
 
08.01.05  Expand sub section  Platinum compounds
Carboplatin
(Injection)
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Formulary
traffic lightRed
  • 150mg/15ml, 450mg/45ml, 50mg/5ml and 600mg/60ml infusion
 
 
Cisplatin
(Injection)
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Formulary
traffic lightRed
  • 10mg/10ml, 50mg/50ml and 100mg/100ml infusion
 
 
Oxaliplatin
(Injection)
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Formulary
traffic lightRed
  • 50mg/10ml, 100mg/20ml and 200mg/40ml infusion
 
Link  NICE TA100: Colon cancer (adjuvant) - capecitabine and oxaliplatin
 
08.01.05  Expand sub section  Procarbazine
Procarbazine
(Capsules)
View adult BNF View SPC online
Formulary
traffic lightRed
  • 50mg capsules

 

 
 
08.01.05  Expand sub section  Protein kinase inhibitors to top
Afatinib
(Tablets)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 20mg, 30mg, 40mg and 50mg tablets
 
Link  NICE TA310: Afatinib for treating epidermal growth factor receptor mutation-positive locally advanced or metastatic non-small-cell lung cancer
 
Cabozantinib
(Oral)
View adult BNF View SPC online
Formulary
traffic lightRed
 
Link  NICE TA463 : Cabozantinib for previously treated advanced renal cell carcinoma
Link  NICE TA516: Cabozantinib for treating medullary thyroid cancer
Link  NICE TA542: Cabozantinib for untreated advanced renal cell carcinoma
 
Crizotinib
(Tablets)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England

 

 
Link  NICE TA406: Crizotinib for untreated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer
Link  NICE TA422: Crizotinib for previously treated anaplastic lymphoma kinase-positive advanced non-small-cell lung cance
 
Dasatinib
(Tablets)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 20mg, 50mg, 80mg, 100mg and 140mg tablets

 

 
Link  NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
 
Entrecitinib
(Capsules)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 100mg, 200mg capsules 
  • Use in line with NICE TA643 and 644
 
Link  NICE TA 644 Entrectinib for treating NTRK fusion-positive solid tumours
Link  NICE TA643 Entrectinib for treating ROS1-positive advanced non-small-cell lung cancer
 
Everolimus (Afinitor®)
(Tablets)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 2.5mg, 5mg and 10mg tablets
  • Ensure correct brand is prescribed.

 

 
Link  NICE TA421: Everolimus with exemestane for treating advanced breast cancer after endocrine therapy
Link  NICE TA432: Everolimus for advanced renal cell carcinoma after previous treatment
Link  NICE TA449 : Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
Link  NICE TA498: Lenvatinib with everolimus for previously treated advanced renal cell carcinoma
 
Everolimus (Votubia®)
(Tablets)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
BlueTeq
  • Only at RUH
  • 2.5mg, 5mg and 10mg tablets
  • Ensure correct brand is supplied
  • To be prescribed by specialist centres in accordance with NHSE commissioning policies
 
Link  Clinical Commissioning Policy: Everolimus for refractory focal onset seizures associated with tuberous sclerosis complex (ages 2 years and above)
Link  Clinical Commissioning Policy: Everolimus for refractory focal onset seizures associated with tuberous sclerosis complex (ages 2 years and above)
 
Gefitinib
(Tablets)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 250mg tablets
 
Link  NICE TA192: Lung cancer (non-small-cell, first line) - gefitinib
Link  NICE TA374: Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy
 
Gilteritinib
(Tablets)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 40mg tablets
  • Use in line with NICE TA642
 
Link  NICE TA642 Gilteritinib for treating relapsed or refractory acute myeloid leukaemia
 
Imatinib (Gilvec®)
(Tablets)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 100mg and 400mg tablets
  • Ensure correct brand supplied

 

 

 
Link  NICE TA326: Imatinib for the adjuvant treatment of gastrointestinal stromal tumours
 
Imatinib (Generic)
(Tablets)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 100mg and 400mg tablets
  • Also for treatment of Philadelphia Positive Guidelines ALL as per BCSH Guidelines

 

 
Link  NICE TA425 Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426 Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
 
Nilotinib
(Capsules)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 150mg and 200mg capsules
 
Link  NICE TA241: Dasatinib, nilotinib and high dose imatinib for CML
Link  NICE TA251: Dasatinib, nilotinib and imatinib for first line treatment of CML
Link  NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
 
Pazopanib
(Tablets)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 200mg and 400mg tablets
 
Link  NICE TA215: Pazopanib in renal cell cancer
 
Regorafenib
(Tablets)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 40mg tablets

 

 
Link  NICE TA488: Regorafenib for previously treated unresectable or metastatic gastrointestinal stromal tumours
Link  NICE TA555: Regorafenib for previously treated advanced hepatocellular carcinoma
 
Sorafenib
(Tablets)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 200mg tablets

 

 
Link  NICE TA474: Sorafenib for treating advanced hepatocellular carcinoma
Link  NICE TA535: Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine
 
Sunitinib
(Capsules)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 12.5mg, 25mg and 50mg capsules

 

 
Link  NICE TA169: Renal cell carcinoma - sunitinib
Link  NICE TA179: Gastrointestinal stromal tumours - sunitinib
Link  NICE TA449 : Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
 
Tivozanib
(Capsules)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 890microgram and 1340microgram capsules

 

 
Link  NICE TA512: Tivozanib for treating advanced renal cell carcinoma
Link  Tivozanib for treating advanced renal cell carcinoma
 
Vemurafenib
(Tablets)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 240mg tablets
 
Link  NICE TA269: Vemurafenib for treating malignant melanoma
 
08.01.05  Expand sub section  Taxanes
Cabazitaxel
(Injection)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 60mg/1.5ml infusion
 
Link  NICE TA391: Cabazitaxel for hormone-relapsed metastatic prostate cancer treated with docetaxel
 
Docetaxel
(Injection)
View adult BNF View SPC online
Formulary
traffic lightRed
  • Various concentrations of infusion
 
Link  NICE TA101: Prostate cancer (hormone-refractory) - docetaxel
Link  NICE TA109: Breast cancer (early) - docetaxel
 
Paclitaxel
(Injection)
View adult BNF View SPC online
Formulary
traffic lightRed
  • Various strengths of concentration
 
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
Link  NICE TA476: Paclitaxel as albumin-bound nanoparticles with gemcitabine for untreated metastatic pancreatic cancer
 
Paclitaxel (Abraxane®)
(Injection)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 100mg infusion
 
Link  NICE TA476: Paclitaxel as albumin-bound nanoparticles with gemcitabine for untreated metastatic pancreatic cancer
 
08.01.05  Expand sub section  Topoisomerase I inhibitors
Irinotecan hydrochloride
(Injection )
View adult BNF View SPC online
Formulary
traffic lightRed
  • 500mg/25ml, 300mg/15ml, 100mg/5ml and 40mg/2ml infusion
 
Link  MHRA Drug Safety Update (Mar 2019):Onivyde (irinotecan, liposomal formulations): reports of serious and fatal thromboembolic events
 
Topotecan
(Injection)
View adult BNF View SPC online
Formulary
traffic lightRed
  • 4mg/4ml infusion

 

 
Link  NICE TA183: Cervical cancer (recurrent) - topotecan
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
 
Topotecan
(Capsules)
View adult BNF View SPC online
Formulary
traffic lightRed
  • 250microgram and 1mg capsules
 
Link  NICE TA184: Lung cancer (small-cell) - topotecan
 
08.01.05  Expand sub section  Trabectedin
Trabectedin
(Injection)
View adult BNF View SPC online
Formulary
traffic lightRed
  • 250microgram and 1mg infusion
 
Link  NICE TA185: Soft tissue sarcoma - trabectedin
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
 
08.01.05  Expand sub section  Trastuzumab
Pertuzumab
(Injection)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 420mg/14ml infusion

 

 
Link  NICE TA424: Pertuzumab for the neoadjuvant treatment of HER2-positive breast cancer
Link  NICE TA509: Pertuzumab with trastuzumab and docetaxel for treating HER2-positive breast cancer
Link  NICE TA569: Pertuzumab for adjuvant treatment of HER2-positive early stage breast cancer
 
Trastuzumab
(Injection)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 600mg/5ml injection  Herceptin®
  • 150mg and 420mg infusion Ontruzant®  
  • Prescribe by brand.  Biosimilar Ontruzant first line option

 

 
Link  NICE TA208: Gastric cancer (HER2-positive metastatic) - trastuzumab
Link  NICE TA257: in combination with an aromatase inhibitor for HER2 positive metastatic breast cancer
Link  NICE TA34: Breast cancer - trastuzumab
 
Trastuzumab emtansine
(Kadcyla®)
(Injection)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 100mg and 160mg infusion

 

 
Link  NICE TA458 : Trastuzumab emtansine for treating HER2-positive advanced breast cancer after trastuzumab and a taxan
 
08.01.05  Expand sub section  Tretinoin to top
Tretinoin
(Capsules)
View adult BNF View SPC online
Formulary
traffic lightRed
  • 10mg capsules
 
 
08.01.05  Expand sub section  Vismodegib
 ....
 Non Formulary Items
Anamorelin

View adult BNF View SPC online
Non Formulary
 
Anamorelin

View adult BNF View SPC online
Non Formulary
 
Carmustine
(Implant)

View adult BNF View SPC online
Non Formulary
Red
  • 7.7mg implant
  • Non Formulary except when used within a specialist centre as per NICE TA
Link  NICE TA121: Glioma (newly diagnosed and high grade) - carmustine implants and temozolomide
 
Chlorambucil (Leukeran®)
(Tablets)

View adult BNF View SPC online
Non Formulary
Red
  • 2mg tablets
 
Dexrazoxane

View adult BNF View SPC online
Non Formulary
High Cost Medicine

For anthracycline extravasation

 
Disodium Levofolinate
(Lvofolinic acid )

View adult BNF View SPC online
Non Formulary
 
Olaratumab (Lartruvo®)

View adult BNF View SPC online
Non Formulary
High Cost Medicine

Discontinued

 
Oxaliplatin

View adult BNF View SPC online
Non Formulary
Red
 
Raltitrexed

View adult BNF View SPC online
Non Formulary
Red
 
Rociletinib

View adult BNF View SPC online
Non Formulary
 
Sonidegib (Odomzo®)

View adult BNF View SPC online
Non Formulary
 
Thiotepa

View adult BNF View SPC online
Non Formulary
 
Tioguanine

View adult BNF View SPC online
Non Formulary
Red
 
Treosulfan

View adult BNF View SPC online
Non Formulary

Commissioned as per national guidance in combination with Fludarabine in line with NICE TA640. Condition not treated at GWH/RUH/SFT

Link  NICE TA 640 Treosulfan with fludarabine for malignant disease before allogeneic stem cell transplant
 
Vismodegib
(Capsules)

View adult BNF View SPC online
Non Formulary
Red
High Cost Medicine
  • 150mg capsule
  • Not recommended by NICE

 

Link  NICE TA489: Vismodegib for treating basal cell carcinoma
 
Vosaroxin (Qinprezo)

View adult BNF View SPC online
Non Formulary
High Cost Medicine
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG
Blueteq
High Cost Drug Approval System

Traffic Light Status Information

Status Description

Traffic LightRed

RED - Hospital only – to be prescribed by a specialist and supplied from secondary care ONLY throughout treatment.  

Traffic LightAmber

Amber medicines are considered suitable for GP prescribing following specialist initiation or recommendation.  

Traffic LightAmber with Shared Care

Shared Care - these medicines require specialist initiation and stabilisation. Ongoing division of responsibility for drug and disease monitoring between specialist and GP by a Shared Care Guideline (SCG). If no SCG in place status reverts to red.  

Traffic LightGreen

These medicines are appropriate for initiation in both primary and secondary care. Prescribing is appropriate within licensed or local recommendations.  

Traffic LightSelf

Suitable for patient to be directed to buy themselves  

Traffic LightGrey

Not currently used. We intend to include this TLS in future to highlight where a decision to use this medicine is under review.   

Traffic LightBlack

(In use from Oct 2020) Used where a decision has been made by the BSW APC not to routinely commission this preparation for its licensed indications. Do not prescribe.   

Traffic LightRed Specialist Centre

Not currently used. We intend to include this TLS in future to highlight where this medicine and indication is ONLY available through a Specialist Centre according to a NICE Highly Specialised Technology or NHSE Specialised Commission Circular / Policy.  

netFormulary