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Royal United Hospitals Bath NHS Foundation Trust
Great Western Hospitals NHS Foundation Trust
Salisbury NHS Foundation Trust
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 Formulary Chapter 8: Malignant disease and immunosuppression - Full Chapter
Notes:

Hameatology/Oncology related Prescribing Guidance

Please see our Prescribing Guidelines page for all prescribing guidance relating to this chapter.

Haematology/Oncology related Shared Care Agreements

Please see our Shared Care Agreements page for all shared care agreements (SCAs) relating to this chapter.

 

 Details...
08.01.05  Expand sub section  Other antineoplastic drugs
08.01.05  Expand sub section  Amsacrine
08.01.05  Expand sub section  Arsenic trioxide
08.01.05  Expand sub section  Bortezomib
08.01.05  Expand sub section  Brentuximab vedotin to top
08.01.05  Expand sub section  Cetuximab
08.01.05  Expand sub section  Dacarbazine and Temozolomide
08.01.05  Expand sub section  Erlotinib
08.01.05  Expand sub section  Hydroxycarbamide
08.01.05  Expand sub section  Ipilimumab to top
08.01.05  Expand sub section  Pentostatin
08.01.05  Expand sub section  Platinum compounds
08.01.05  Expand sub section  Procarbazine
08.01.05  Expand sub section  Protein kinase inhibitors
Afatinib
(Tablets)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 20mg, 30mg, 40mg and 50mg tablets
 
Link  NICE TA310: Afatinib for treating epidermal growth factor receptor mutation-positive locally advanced or metastatic non-small-cell lung cancer
 
Cabozantinib
(Oral)
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Formulary
traffic lightRed
 
Link  NICE TA463 : Cabozantinib for previously treated advanced renal cell carcinoma
Link  NICE TA516: Cabozantinib for treating medullary thyroid cancer
Link  NICE TA542: Cabozantinib for untreated advanced renal cell carcinoma
 
Crizotinib
(Tablets)
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Formulary
traffic lightRed
High Cost Medicine
NHS England

 

 
Link  NICE TA406: Crizotinib for untreated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer
Link  NICE TA422: Crizotinib for previously treated anaplastic lymphoma kinase-positive advanced non-small-cell lung cance
 
Dasatinib
(Tablets)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 20mg, 50mg, 80mg, 100mg and 140mg tablets

 

 
Link  NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
 
Entrecitinib
(Capsules)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 100mg, 200mg capsules 
  • Use in line with NICE TA643 and 644
 
Link  NICE TA 644 Entrectinib for treating NTRK fusion-positive solid tumours
Link  NICE TA643 Entrectinib for treating ROS1-positive advanced non-small-cell lung cancer
 
Everolimus (Afinitor)
(Tablets)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 2.5mg, 5mg and 10mg tablets
  • Ensure correct brand is prescribed.

 

 
Link  NICE TA421: Everolimus with exemestane for treating advanced breast cancer after endocrine therapy
Link  NICE TA432: Everolimus for advanced renal cell carcinoma after previous treatment
Link  NICE TA449 : Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
Link  NICE TA498: Lenvatinib with everolimus for previously treated advanced renal cell carcinoma
 
Everolimus (Votubia)
(Tablets)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
BlueTeq
  • Only at RUH
  • 2.5mg, 5mg and 10mg tablets
  • Ensure correct brand is supplied
  • To be prescribed by specialist centres in accordance with NHSE commissioning policies
 
Link  Clinical Commissioning Policy: Everolimus for refractory focal onset seizures associated with tuberous sclerosis complex (ages 2 years and above)
Link  Clinical Commissioning Policy: Everolimus for refractory focal onset seizures associated with tuberous sclerosis complex (ages 2 years and above)
 
Gefitinib
(Tablets)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 250mg tablets
 
Link  NICE TA192: Lung cancer (non-small-cell, first line) - gefitinib
Link  NICE TA374: Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy
 
Gilteritinib
(Tablets)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 40mg tablets
  • Use in line with NICE TA642
 
Link  NICE TA642 Gilteritinib for treating relapsed or refractory acute myeloid leukaemia
 
Imatinib (Gilvec)
(Tablets)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 100mg and 400mg tablets
  • Ensure correct brand supplied

 

 

 
Link  NICE TA326: Imatinib for the adjuvant treatment of gastrointestinal stromal tumours
 
Imatinib (Generic)
(Tablets)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 100mg and 400mg tablets
  • Also for treatment of Philadelphia Positive Guidelines ALL as per BCSH Guidelines

 

 
Link  NICE TA425 Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426 Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
 
Nilotinib
(Capsules)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 150mg and 200mg capsules
 
Link  NICE TA241: Dasatinib, nilotinib and high dose imatinib for CML
Link  NICE TA251: Dasatinib, nilotinib and imatinib for first line treatment of CML
Link  NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
 
Pazopanib
(Tablets)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 200mg and 400mg tablets
 
Link  NICE TA215: Pazopanib in renal cell cancer
 
Regorafenib
(Tablets)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 40mg tablets

 

 
Link  NICE TA488: Regorafenib for previously treated unresectable or metastatic gastrointestinal stromal tumours
Link  NICE TA555: Regorafenib for previously treated advanced hepatocellular carcinoma
 
Sorafenib
(Tablets)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 200mg tablets

 

 
Link  NICE TA474: Sorafenib for treating advanced hepatocellular carcinoma
Link  NICE TA535: Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine
 
Sunitinib
(Capsules)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 12.5mg, 25mg and 50mg capsules

 

 
Link  NICE TA169: Renal cell carcinoma - sunitinib
Link  NICE TA179: Gastrointestinal stromal tumours - sunitinib
Link  NICE TA449 : Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
 
Tivozanib
(Capsules)
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Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 890microgram and 1340microgram capsules

 

 
Link  NICE TA512: Tivozanib for treating advanced renal cell carcinoma
Link  Tivozanib for treating advanced renal cell carcinoma
 
Vemurafenib
(Tablets)
View adult BNF View SPC online
Formulary
traffic lightRed
High Cost Medicine
NHS England
  • 240mg tablets
 
Link  NICE TA269: Vemurafenib for treating malignant melanoma
 
08.01.05  Expand sub section  Taxanes to top
08.01.05  Expand sub section  Topoisomerase I inhibitors
08.01.05  Expand sub section  Trabectedin
08.01.05  Expand sub section  Trastuzumab
08.01.05  Expand sub section  Tretinoin
08.01.05  Expand sub section  Vismodegib to top
 ....
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG
Blueteq
High Cost Drug Approval System

Traffic Light Status Information

Status Description

Traffic LightRed

RED - Hospital only to be prescribed by a specialist and supplied from secondary care ONLY throughout treatment.  

Traffic LightAmber

Amber medicines are considered suitable for GP prescribing following specialist initiation or recommendation.  

Traffic LightAmber with Shared Care

Shared Care - these medicines require specialist initiation and stabilisation. Ongoing division of responsibility for drug and disease monitoring between specialist and GP by a Shared Care Guideline (SCG). If no SCG in place status reverts to red.  

Traffic LightGreen

These medicines are appropriate for initiation in both primary and secondary care. Prescribing is appropriate within licensed or local recommendations.  

Traffic LightSelf

Suitable for patient to be directed to buy themselves  

Traffic LightGrey

Not currently used. We intend to include this TLS in future to highlight where a decision to use this medicine is under review.   

Traffic LightBlack

(In use from Oct 2020) Used where a decision has been made by the BSW APC not to routinely commission this preparation for its licensed indications. Do not prescribe.   

Traffic LightRed Specialist Centre

Not currently used. We intend to include this TLS in future to highlight where this medicine and indication is ONLY available through a Specialist Centre according to a NICE Highly Specialised Technology or NHSE Specialised Commission Circular / Policy.  

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